Vitamin B6 occurs in 3 forms–pyridoxine, pyridoxal, and pyridoxamine. B6 is absorbed in the large intestine. The muscle shops roughly 75-80 % of the vitamin while the live stores about 5 10 %.
B6 is necessary for transaminations, decarboxylations, dehydratases, side chain cleavage reactions, and ammonia release. The aldehyde group of its acts as a Schiff base to act in response with the amino groups of amino acids. It essentially acts to shuttle nitrogen between compounds.
Functions- The 3 types of B6 could all be converted on the coenzyme PLP that aids in transamination and protein metabolism. PLP is vital for glycogen degradation; it also helps with the development of the neurotransmitter, serotonin, the nonprotein portion of hemoglobin (heme), nucleic acids, and lecithin. Vitamin B6 is essential for the metabolic process of tryptophan to niacin.
Overall Reactions:
· Transaminations These responses are necessary to reuse and reuse nitrogen in the human body. They are the first stage of amino acid catabolism as well as the very last phase in the synthesis of nonessential amino acids. Example: a-ketoglutarate + asparate glutamate + oxaloacetate
· Serine/ Threonine Deamination (Dehydratases) This reaction provides the generation of the a keto acids of threonine and serine through oxidative removal of N as ammonia Example: Serine a-keto-serine + NH4+
· Decarboxylation These reactions often occur on the neuroactive amines of seratonin, tyramine, histamine, alpine reviews – yahoo.com, and GABA. Additionally they are crucial in porphyrin synthesis, intermediates in the synthesis of sphingomyelin, taurine and lecithin, and also for the description as well as desulfuration of cysteine.
· Glycogen Phosphorylase fifty % of all B6 in the body is certain to glycogen phosphorylase however, the value is unknown. The reaction is vital for recycling of folate and it is as follows: